About Placenta Accreta

Overview

Placenta accreta, also known as placental adhesion disorder, is a condition where the placenta attaches and grows deeply into the wall of the uterus (womb). Placenta accreta involves the placental tissue invading the myometrium (the muscular layer of the uterus). This invasion prevents the placenta from separating naturally after delivery. Without treatment, this condition can lead to severe postpartum hemorrhage (excessive bleeding after childbirth) and shock.

This condition is classified based on the depth of uterine invasion by the placental tissue. There are three types of placenta accreta:

  • Placenta accreta vera: The placenta is abnormally fixed directly into the myometrium.
  • Placenta increta: The placenta partially invades the myometrium.
  • Placenta percreta: The placenta fully invades the myometrium and extends to or beyond the uterus, sometimes even reaching adjacent organs.

The major risk factors for developing placenta accreta include a history of previous cesarean sections and placenta previa (when the placenta partially or completely covers the cervix). Other less common risk factors may include a history of conservative myomectomy (removal of uterine fibroids), uterine artery embolization (a procedure to block blood flow to fibroids), curettage (scraping of the uterine lining), or uterine rupture. Older maternal age is also considered a risk factor.

Placenta accreta can lead to complications such as third trimester vaginal bleeding, severe postpartum hemorrhage (excessive bleeding after childbirth), cesarean delivery, and sometimes even require a hysterectomy (removal of the uterus). Therefore, accurate prenatal diagnosis of this condition is crucial for ensuring the safety of both the mother and fetus before delivery. Medical imaging examinations, particularly magnetic resonance imaging (MRI), play an important role in diagnosing and localizing these abnormalities.

Causes and Risk Factors

Non-modifiable risk factors for placenta accreta are factors that can’t be changed. These include:

  • Older maternal age: Women who are older, typically over the age of 35, have a higher risk of developing placenta accreta.
  • Placenta previa: This condition occurs when the placenta covers the cervix, increasing the risk of placenta accreta.
  • Prior cesarean section (C-section): Women who have had previous cesarean deliveries are at a higher risk of developing placenta accreta.
  • Prior uterine surgery: Any surgery on the uterus, such as myomectomy or removal of fibroids, can increase the risk of placenta accreta.

Modifiable risk factors for placenta accreta are factors that can be influenced or changed, including:

  • Induced abortion: Having a history of induced abortions may increase the risk of developing placenta accreta.
  • Uterine malformation: Certain abnormalities in the shape or structure of the uterus can contribute to the development of placenta accreta.
  • Endometrial infection: Infections in the lining of the uterus can lead to damage that increases the risk of placenta accreta.

It is important to note that while some risk factors for placenta accreta are modifiable, such as induced abortion or uterine malformation, others like advanced maternal age or prior C-section cannot be changed. It is essential for healthcare providers to identify these risk factors during prenatal care to provide appropriate management and reduce potential complications during childbirth.

Symptoms

The most common early symptom of placenta accreta is painless vaginal bleeding that occurs in the third trimester of pregnancy. This bleeding can range from mild to severe. It's important to note that this symptom can be easily overlooked or mistaken for another issue, so it's crucial to seek medical attention if any vaginal bleeding occurs during pregnancy.

As Placenta Accreta progresses or reaches higher severity, there may be additional symptoms that can occur. These symptoms can include:

  • Back or abdominal (stomach) pain: This pain may be felt in the lower back or lower abdomen.
  • Antepartum hemorrhage: This refers to bleeding that happens before childbirth and can be a more severe form of vaginal bleeding.
  • Retained placenta: In some cases, part of the placenta may remain in the womb after childbirth. If this happens, a medical procedure may be needed to remove the placenta.
  • Placental insufficiency: This occurs when the placenta is unable to provide enough oxygen and nutrients to the fetus, which can lead to complications during pregnancy.

It's important to remember that placenta accreta is a serious condition that requires medical attention. If you experience any symptoms or have concerns about your pregnancy, it's best to consult with your healthcare provider for proper evaluation and guidance.

Diagnosis

The most commonly used methods for diagnosing placenta accreta are ultrasound and magnetic resonance imaging (MRI) scan. Ultrasound is preferred because it is low-cost, non-invasive, and simple to perform. It can determine the location and predict the status of placenta accreta. However, ultrasound has some limitations. It can be affected by factors such as operator technique, placental location, the amount of amniotic fluid, and the thickness of fat tissue in the pregnant woman's abdominal wall. These factors can lead to unclear visualization of the placenta on the back wall of the uterus. MRI scan may be beneficial in some cases.

To diagnose placenta accreta, ultrasound is combined with MRI to increase accuracy.

To determine the stage or severity of placenta accreta, additional examinations, tests, and procedures may be performed, including:

  • Macroscopic and histopathological analysis: This involves analyzing the physical appearance and microscopic characteristics of the placenta. It helps evaluate the extent of placental invasion into the uterine wall.
  • Postoperative histopathological evaluation: The definite diagnosis of placenta sccreta is made after evaluating tissue samples from postoperative procedures.
  • Maternal characteristics: Maternal characteristics such as age, gravidity (number of pregnancies), parity (number of live births), history of abortion, previous Dilatation and Curettage (D&C) procedures, C-sections, and other uterine surgeries are recorded.

These examinations, tests, and procedures help in accurately diagnosing placenta accreta and determining its stage or severity.

Treatment Options

The goals of treatment for placenta accreta are to minimize maternal complications, control hemorrhage, and preserve fertility when desired. There are several treatment options that can be used to achieve these goals, including:

  • Antibiotic treatment: Antibiotics are medications that help fight off infections caused by bacteria. In the case of placenta accreta, antibiotic treatment is recommended to prevent or treat any infection that may occur. This helps reduce the risk of complications and promotes healing.
  • Interventional therapy: In the case of placenta accreta, interventional therapy can include techniques such as uterine artery embolization (UAE). UAE involves using radiographic identification of the bleeding vessels and occluding their flow with gelfoam, coils, or glue. This procedure helps control bleeding.
  • Ultrasound-Guided Curettage: Curettage is a procedure in which tissue is removed from the uterus. In the context of placenta accreta, ultrasound-guided curettage may be performed within 24 hours following vaginal delivery as a conservative management strategy. This procedure helps remove any remaining placental tissue and promotes healing.
  • Surgical Hemostasis: Surgical hemostasis refers to techniques used during surgery to control bleeding. During a C-section for placenta accreta, surgical hemostasis methods are employed to manage intraoperative hemorrhage and preserve the uterus. These methods may include various techniques such as suturing and other approaches to minimize bleeding.
  • Hysterectomy: Hysterectomy is the surgical removal of the uterus. It is considered the definitive treatment for placenta accreta when other methods fail to control bleeding or when fertility preservation is not desired. Hysterectomy removes the source of bleeding and eliminates the risk of further complications associated with placenta accreta.

It's important to note that treatment for placenta accreta should be carried out by an experienced multidisciplinary team. This ensures that all aspects of care are addressed effectively and minimizes potential risks or complications. Additionally, diagnosis during pregnancy using imaging techniques such as ultrasound and MRI plays a crucial role in planning treatment for placenta accreta, allowing for early detection and intervention if necessary.

Progression or Complications

Complications commonly associated with placenta accreta include:

  • Postpartum hemorrhage: Placenta accreta can cause significant bleeding after delivery, which may require blood transfusions or even emergency hysterectomy (removal of the uterus) to control the bleeding.
  • Maternal mortality: Placenta accreta can increase the risk of maternal death due to severe bleeding and other life-threatening complications.
  • Neonatal complications: Placenta accreta may result in preterm delivery (delivery before 37 weeks), stillbirth, and asphyxia (lack of oxygen), leading to potential neonatal morbidity and admission to neonatal intensive care units.
  • Uterine perforation: In some cases, the invasive placental tissue can penetrate through the uterine wall, causing uterine perforation, which is a serious complication requiring immediate medical attention.

To manage placenta accreta and reduce complications, treatment options are available. The goal of treatment is to ensure the safety of both the mother and fetus.

It's important to note that treatment options should be discussed with healthcare professionals who can provide personalized advice based on individual circumstances. If you suspect you have placenta accreta or any other health concerns, it's always best to consult your doctor for proper evaluation and guidance tailored to your specific needs.