About Rectovaginal Fistula

Overview
A rectovaginal fistula (RVF) is an abnormal connection between the rectum and the vagina. This means that there is an abnormal passageway that forms between these two organs, allowing stool and gas to leak from the rectum into the vagina. RVFs can occur due to various reasons such as childbirth injuries, surgical complications, inflammatory bowel diseases, or local infections. They can cause discomfort and affect a person's quality of life. Treatment for RVFs involves surgery.
Causes and Risk Factors

Causes of rectovaginal fistula include:

  • Obstetric complications or gynecologic procedures: Some of the most common causes are surgeries following complications during childbirth or gynecologic procedures, such as hysterectomies.
  • Pelvic tumors: Tumors in the pelvic region can cause tissue destruction, leading to the formation of a fistula.
  • Inflammatory bowel diseases: Conditions like Crohn's disease can increase the risk of developing a rectovaginal fistula.
  • Radiation treatment: Radiation therapy for cancers in the pelvic area, such as cervical cancer, can lead to fistula formation.
  • Infections: Certain infections like abscesses or diverticulitis can contribute to the development of a rectovaginal fistula.

Non-modifiable risk factors are risk factors that cannot be changed. Non-modifiable risk factors of rectovaginal fistula:

  • Long and difficult labor: Women who have experienced a long and difficult labor are at an increased risk of developing a rectovaginal fistula.
  • Previous cancer or radiation treatment: Individuals who have had cancer in the vagina, cervix, rectum, uterus, or anus, or have undergone radiation therapy for these cancers are more prone to develop a rectovaginal fistula.
  • Crohn's disease or ulcerative colitis: People with inflammatory bowel diseases like Crohn's disease have an increased risk of developing a rectovaginal fistula. However, managing these conditions effectively through medical treatment and lifestyle modifications may help reduce the risk.

Modifiable risk factors are risk factors that can be changed or influenced. Modifiable risk factors of rectovaginal fistula:

  • Smoking: Smoking has been identified as a modifiable risk factor for rectovaginal fistulas. Quitting smoking can not only improve overall health but also potentially decrease the risk of developing this condition.
  • Diabetes and obesity: Conditions like diabetes and obesity are associated with an increased risk of complications after surgery, including the formation of fistulas. Maintaining a healthy weight and managing diabetes effectively may help reduce this risk.

It's important to note that while these factors may increase the likelihood of developing a rectovaginal fistula, not everyone with these factors will develop the condition. Each person's individual circumstances and health should be taken into consideration when assessing their risk.

Symptoms

A rectovaginal fistula can cause a range of symptoms, both in the early stages and as the condition progresses. Here are the most common early symptoms of rectovaginal fistula:

  • Inflammation: This can cause redness, swelling, and discomfort.
  • Passage of gas or feces through the vagina: This can be distressing and embarrassing for those experiencing it.
  • Foul odor: This odor can be persistent and difficult to manage.

As rectovaginal fistula progresses or becomes more severe, additional symptoms may occur, including:

  • Bleeding: This can occur due to irritation and inflammation in the affected area.
  • Recurrent urinary tract or vaginal infections: The abnormal connection between the rectum and vagina can increase the risk of recurrent infections in both the urinary tract and vagina. These infections may cause symptoms such as pain, discomfort, and increased frequency of urination.
  • Pain and inflammation: As the condition worsens, individuals may experience pain and inflammation in the area between the vagina, colon, and external vaginal tissues. This can make daily activities uncomfortable and may also affect sexual activities.
  • Trouble controlling stool: In more advanced cases, rectovaginal fistula can lead to difficulty controlling the passage of stool, known as fecal incontinence. This can significantly impact quality of life and require additional management strategies.
  • Abscess formation: In some instances, an abscess (a pus-filled sore) may develop within the fistula tract. This can cause pain, swelling, and further complications.
Diagnosis

To diagnose a rectovaginal fistula, doctors typically perform a series of examinations, tests, and procedures. These help them identify the presence of the fistula and determine its severity or stage. Here are the commonly used methods:

Medical and surgical history review:

  • Doctors will review a person's medical and surgical history to identify possible causes of the fistula, such as recent pelvic surgery, childbirth, radiation therapy in the pelvic area, or conditions like Crohn's disease.

Physical Exam:

  • A thorough physical and pelvic exam is performed by the doctor.
  • They may use a gloved hand to check the vagina, anus, and perineum (the area between the vagina and anus).
  • Examination Under Anesthesia (EUA): EUA can be considered as a primary procedure to avoid any delay in diagnosis when MRI or endoanal ultrasound is not available. It can provide valuable information about the extent and complexity of the fistula.

Imaging tests:

  • Additional imaging tests such as MRIs, CTs, or ultrasounds may be ordered to confirm the presence of a rectovaginal fistula and rule out other conditions.

It's important to note that these examinations, tests, and procedures are conducted by healthcare professionals to accurately diagnose rectovaginal fistulas. If you suspect you have a rectovaginal fistula or have symptoms related to it, it's crucial to consult with a healthcare provider for proper evaluation and guidance.

Treatment Options

The goals of treatment for RVF are to close the abnormal opening between the rectum and vagina, promote healing of the surrounding tissues, and restore normal bowel function. Here are the different treatment options and how they work to achieve these goals:

  • Surgery: The main treatment for RVF is surgery. During the surgery, a piece of tissue is taken from another part of the body to create a flap or plug that closes the abnormal opening. The surgeon may also repair any damaged anal sphincter muscles. The specific surgical approach can be through the abdomen, vagina, or perineum. In some cases, a colostomy may be necessary. This procedure creates an opening in the belly wall where the end of the large intestine is brought out and waste is collected in a bag until the fistula heals.
  • Antibiotics: If there is an infection present, antibiotics may be prescribed to treat the infection before surgery can be performed. This helps to reduce inflammation and promote healing of the tissues around the fistula.
  • Tumor necrosis factor-alpha (TNF-alpha) inhibitors: In cases where RVF is associated with Crohn's disease, these medications may be used to bring down inflammation. Infliximab is a medication that works by targeting specific proteins in the body's immune system that contribute to inflammation.
  • Fibrin sealants: For small and low RVFs in the course of inflammatory bowel diseases (IBD), such as ulcerative colitis (UC), fibrin sealants may be applied locally as an alternative to surgery. Fibrin sealants help to promote tissue healing and close the fistula.
  • Stem cells: There is ongoing research exploring the use of stem cells for treating RVF in patients with IBD. Stem cells have regenerative properties that may aid in tissue repair and closure of the fistula.
  • Platelet-rich plasma (PRP): Another experimental therapy being studied for RVF in patients with UC is local application of PRP. PRP contains a concentrated amount of platelets, which release growth factors that promote tissue healing and regeneration.
Progression or Complications

The natural progression of rectovaginal fistula over time can vary depending on factors such as the size and location of the fistula, the quality of surrounding tissue, and any underlying systemic disorders.

Complications commonly associated with rectovaginal fistula include:

  • Trouble controlling the passage of stool
  • Repeated urinary tract or vaginal infections
  • Inflammation of the vagina or perineum
  • Pus-filled sore (abscess) in the fistula
  • Development of another fistula after treatment

In summary, rectovaginal fistula can have a significant impact on a person's quality of life. Surgical interventions are often necessary but should be tailored to each individual case. Consulting with a healthcare professional is essential for appropriate diagnosis and management of rectovaginal fistula.