About Peripheral Neuropathy

Overview
Peripheral neuropathy refers to damage or dysfunction of the peripheral nerves, which are responsible for transmitting signals between the central nervous system (brain and spinal cord) and the rest of the body. It is a common condition that typically affects the feet and legs but can also involve the hands and arms. The symptoms of peripheral neuropathy can vary but often include pain, numbness, tingling, and weakness in the affected areas. There are many different causes of peripheral neuropathy, including diabetes, excessive alcohol consumption, certain vitamin deficiencies, and unknown factors. It is estimated that more than 20 million people in the United States have some form of peripheral neuropathy. Diagnosis and treatment should be guided by a healthcare professional.
Causes and Risk Factors

Peripheral neuropathy can have various causes, including:

  • Diabetes: Diabetes is one of the most common causes of peripheral neuropathy. About 60 to 70 percent of people with diabetes develop some form of neuropathy.
  • Trauma: Injuries such as broken bones, burns, and other traumatic events can result in temporary or permanent nerve damage.
  • Repetitive motion: Repeated movements can lead to inflammation in muscles, tendons, and other tissues, which can compress and damage nerves.
  • Vasculitis: Chronic inflammation can cause scar tissue formation in blood vessel walls, affecting normal blood flow to the nerves.
  • Autoimmune diseases: Certain autoimmune conditions can launch attacks on the peripheral nervous system.

Non-modifiable risk factors for peripheral neuropathy include:

  • Duration of diabetes: The length of time a person has had diabetes can contribute to the development of neuropathy.
  • Family history: Having a family history of diabetic complications may increase the risk of peripheral neuropathy.

Modifiable risk factors for peripheral neuropathy include:

  • Residence: The place where a person lives may influence their risk of developing peripheral neuropathy.
  • Fasting blood glucose level: Maintaining a healthy blood glucose level is crucial in preventing or managing peripheral neuropathy.
  • Method of glycemic control: The approach used to control blood sugar levels, such as through diet, exercise, or medication, can impact the risk of neuropathy.
  • High blood pressure/hypertension: Controlling blood pressure levels is important in reducing the risk of peripheral neuropathy.
  • Physical activity: Engaging in regular physical exercise for at least 45 minutes three times per week is associated with a lower risk of developing neuropathy.
  • Waist circumference: Reducing central obesity can help decrease the risk of peripheral neuropathy.

It's important to note that these factors are based on studies and observations. For personalized advice and guidance regarding your specific situation, it's best to consult with your healthcare professional.

Symptoms

The most common early symptoms of peripheral neuropathy include:

  • Loss of sensation in the extremities
  • Burning or tingling sensation
  • Pins and needles sensation
  • Numbness
  • Weakness
  • Pain, which can be severe and may occur even with light touch
  • Problems sensing pain or temperature in the affected areas

As peripheral neuropathy progresses or reaches higher severity, additional symptoms may occur. These can include:

  • Changes in walking pattern
  • Loss of balance, leading to an increased risk of falls
  • Loss of muscle tone in the hands and feet
  • Difficulty sensing movement or position
  • Swollen feet

It's important to note that symptoms are often worse at night and can affect both sides of the body. However, it is possible to experience symptoms on only one side. If you are experiencing any of these symptoms, it is recommended to consult with your healthcare professional for an accurate diagnosis and appropriate management.

Diagnosis

To diagnose peripheral neuropathy, doctors commonly perform the following examinations, tests, and procedures:

  • Physical Exam: This includes a neurological exam to assess nerve function and a foot exam to check for signs of problems and evaluate blood flow and sensation in the feet.
  • Monofilament Test: A nylon strand is used to test if you can feel it when touched to your feet, assessing your ability to perceive sensations.
  • Tuning Fork Test: A tuning fork is placed against your great toes and higher on your feet to check if you can feel vibrations.
  • Gait Assessment: Your doctor reviews your walking patterns to identify any abnormalities.
  • Balance Testing: Your balance is evaluated to determine if neuropathy affects your coordination.
  • Temperature Sensation Test: Your ability to feel temperature changes in your feet may be assessed.

To determine the stage or severity of peripheral neuropathy, additional examinations, tests, and procedures may include:

  • Nerve Conduction Studies: These tests assess nerve function by measuring nerve conduction velocities and sensory nerve action potentials.
  • Electromyography (EMG): This test evaluates muscle and motor neuron function by recording the electrical activity produced by skeletal muscles.
  • Genetic Testing: In specific cases, genetic testing may be performed to identify underlying genetic causes of neuropathy.
  • Cerebrospinal Fluid (CSF) Examination: CSF analysis may be done to assess for underlying infections or inflammatory conditions affecting the nervous system.
  • Nerve Imaging: Imaging techniques such as MRI or ultrasound may be used to visualize nerves and identify any structural abnormalities.
  • Nerve Biopsy: In certain situations, a small sample of nerve tissue may be taken for further analysis.

Remember, the specific examinations, tests, and procedures recommended for diagnosing and determining the severity of Peripheral Neuropathy may vary depending on individual circumstances. It's important to consult with your healthcare professional for personalized guidance.

Treatment Options

The goals of treatment for peripheral neuropathy are to address the underlying disease process, correct nutritional deficiencies, and provide relief from symptoms. Here are the different types of treatments and how they work towards achieving these goals:

Medication Types:

  • Medications for associated conditions: These medications manage conditions that may be causing neuropathy, such as diabetes or hypothyroidism.
  • Pain medications: Over-the-counter pain relief can help with mild to moderate pain but should not be used long-term.
  • Prescription medications: Antidepressants and seizure medications may help relieve neuropathy symptoms.

Therapies and Therapeutic Procedures:

  • Chiropractic treatment: Chiropractors can help alleviate symptoms of polyneuropathy.
  • Transcutaneous electrical nerve stimulation (TENS): This therapy uses gentle electrical currents to provide pain relief.

Health Behavior Changes:

  • Balanced diet and vitamin supplementation: Nutritional deficiencies can contribute to neuropathy, so maintaining a healthy diet and taking recommended vitamin supplements, such as Vitamin B and D, can help improve nerve health.
  • Exercise and rest: Regular exercise helps strengthen muscles, while adequate rest promotes overall well-being.
  • Smoking cessation and alcohol moderation: Quitting smoking and reducing alcohol consumption can have positive effects on neuropathy symptoms.

Other Treatments:

  • Physical therapy and occupational therapy: These therapies can help manage symptoms and improve day-to-day functioning.
  • Mobility aids: Special shoes, braces, or canes may assist with balance or walking difficulties.
  • Support groups: Connecting with others who have neuropathy can provide emotional support.

Always consult with your healthcare professional for personalized advice regarding medication types and dosing.