About Legg-Calve-Perthes Disease

Overview
Legg-Calve-Perthes disease (LCPD), also known as Perthes disease or avascular necrosis of the hip, is a bone disorder that affects the hips, particularly in children between the ages of 2 and 12. It occurs when there is a temporary loss of blood supply to the top of the thigh bone (femoral head). This leads to a breakdown of the femoral head and changes its shape, making it difficult for it to move smoothly in the hip socket. As a result, children with LCPD may experience symptoms such as hip pain, limping, and restricted leg movement. If left untreated, LCPD can cause long-term issues and increase the risk of developing osteoarthritis in the hips at an early age. Early treatment is important to preserve proper bone and joint development and prevent complications later in life.
Causes and Risk Factors

The causes of Legg-Calve-Perthes disease are still not fully understood. However, it is believed that a disruption of blood supply to the femoral head, leading to death of bone tissue, is a critical factor in the development of LCPD.

Non-modifiable risk factors are risk factors that cannot be changed. Non modifiable risk factors for LCPD include:

  • Age: LCPD typically affects children between the ages of 2 and 12, with the most common age being around 6 to 7 years old.
  • Sex: Boys are more commonly affected by LCPD than girls.
  • Genetic factors: While LCPD is usually not linked to genetics, there have been a few family cases where the condition was passed down in an autosomal dominant way (meaning a child can inherit it if one parent carries the gene).
  • Congenital hip dysplasia: Some children are born with a hip joint that isn't formed correctly. This can put stress on the hip and potentially affect blood flow to the area, making LCPD more likely

Modifiable risk factors are risk factors that can be changed or influenced. Modifiable risk factors for LCPD include:

  • Trauma: Injuries to the hip, like a bad fall or repeated stress, can damage the blood vessels that supply the hip joint, which may lead to the bone tissue dying.
  • Diseases and infections: Some conditions such as sickle-cell crisis, or infections such as toxic synovitis, can affect blood flow to the hip joint
  • Steroid use: Long-term use of certain medications, like corticosteroids, can weaken bones and reduce blood flow to the hip, increasing the risk of bone death in the joint

It's always best to consult with a healthcare professional for specific information and guidance regarding your individual situation.

Symptoms

The most common symptoms of Legg-Calve-Perthes disease include:

  • Limping
  • Pain in the hip, thigh, or knee
  • Reduced range of hip motion

As LCPD progresses or becomes more severe, other symptoms may occur:

  • Leg length discrepancy (one leg longer than the other)
  • Wasting of the muscles around the hip
  • Development of degenerative arthritis in adulthood

Remember to consult with your healthcare professional for an accurate diagnosis and appropriate management.

Diagnosis

To diagnose Legg-Calve-Perthes disease, the following examinations, tests, and procedures are commonly performed:

  • Physical exam and medical history: The healthcare provider will look for physical signs of the disease, such as hip pain, reduced mobility, stiffness, or a limp. They'll also review any past injuries or conditions.
  • Lab tests: These tests involve checking a sample of blood, urine, or body tissues to help diagnose the disease and eliminate possibility of other conditions. The specific type of lab tests ordered will depend on your symptoms and the diseases being considered.
  • Imaging studies: Diagnostic imaging studies allow doctors to look inside the body for clues to help diagnose or manage the disease, and can include:
    • X-rays: This scan is the main tool used to diagnose LCPD. They help show changes in the shape of the femoral head (the ball of the hip joint) and whether the bone is breaking down or flattening.
    • MRI or Bone Scan: If X-rays don’t provide a clear picture, an MRI or bone scan may be used. These imaging tests show more detailed views of the hip joint and can detect early signs of reduced blood flow to the femoral head.

It's important to consult with your healthcare provider about which specific examinations, tests, and procedures are appropriate for your individual situation.

Treatment Options

The goals of treatment for Legg-Calve-Perthes disease are to minimize femoral head deformity and maintain hip motion. Here are the different types of treatments and how they work to achieve these goals:

  • Medication: Pain management medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), may be prescribed to alleviate hip pain and inflammation.
  • Therapies: Physical therapy plays a crucial role in LCPD treatment. It focuses on improving hip range of motion, strengthening the surrounding muscles, and maintaining joint flexibility. This helps prevent muscle contractures and maintains functional mobility.
  • Procedures: Surgical procedures may be considered in certain cases to help keep the femoral head in place and improve hip function. These procedures include pelvic osteotomies (surgery to reshape the pelvic bones) and proximal femoral osteotomies (surgery to cut and realign the upper part of the thigh bone). These surgeries aim to improve hip joint congruence and provide better coverage of the femoral head.
  • Self-care and health behavior changes: Lifestyle modifications can help support the treatment of LCPD. These may include weight management, avoiding high-impact activities, and using assistive devices (such as crutches or braces) to reduce stress on the affected hip.

It's important to note that the choice of treatment depends on various factors, including the age of the patient, stage of LCPD, severity of symptoms, and individual patient characteristics. Consulting with a healthcare professional is crucial for personalized treatment recommendations.

Medication dosing may be affected by many factors. Check with your health care professional about dosing for your individual situation. Side effects can occur. Check with your health care professional or read the information provided with your medication for side effect information.